Protein Domain : Iron-regulated surface determinant protein IsdB IPR019929

Type	Family
Description	Isd proteins are iron-regulated surface proteins found in Bacillus, Staphylococcus and Listeria species and are responsible for haem scavenging from hemoproteins [ ]. The IsdB protein is only observed in Staphylococcus and consists of an N-terminal hydrophobic signal sequence, a pair of tandem NEAT (NEAr Transporter, ) domains which confers the ability to bind haem [ , ] and a C-terminal sortase processing signal which targets the protein to the cell wall. IsdB is believed to make a direct contact with methaemoglobin facilitating transfer of haem to IsdB []. The haem is then transferred to other cell wall-bound NEAT domain proteins such as IsdA and IsdC. It has been shown that IsdA and IsdB co-localise within the Staphylococcal cell wall to discrete sites corresponding to regions of hemoglobin capture [].
Short Name	Iron-reg_IsdB