Protein Domain : Centromere protein Cenp-K IPR020993

Type  Family
Description  Cenp-K is one of seven new Cenp-A-nucleosome distal (CAD) centromere components (the others being Cenp-L, Cenp-O, Cenp-P, Cenp-Q, Cenp-R and Cenp-S) that are identified as assembling on the Cenp-A nucleosome associated complex, NAC []. The Cenp-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival despite continued centromere-derived mitotic checkpoint signalling. Cenp-K is centromere-associated through its interaction with one or more components of the Cenp-A NAC. It may be involved in incorporation of newly synthesized Cenp-A into centromeres via its interaction with the Cenp-A-NAC complex [].The homologue in Schizosaccharomyces pombe is known as inner kinetochore subunit sim4 [ , ].
Short Name  Centromere_CenpK

0 Child Features

0 Gene Families

0 Genes

2 Ontology Annotations

0 Parent Features

0 Publications

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