Protein Domain : SecY conserved site IPR030659

Type	Conserved_site
Description	The eubacterial secY protein [ ] plays an important role in protein export. Itinteracts with the signal sequences of secretory proteins as well as with two other components of the protein translocation system: secA and secE. SecY isan integral plasma membrane protein of 419 to 492 amino acid residues that apparently contains ten transmembrane segments. Such a structure probablyconfers to secY a 'translocator' function, providing a channel for periplasmic and outer-membrane precursor proteins.Homologues of secY are found in archaebacteria [ ]. SecY is also encoded inthe chloroplast genome of some algae [ ] where it could be involved in aprokaryotic-like protein export system across the two membranes of the chloroplast endoplasmic reticulum (CER) which is present in chromophyte andcryptophyte algae. In eukaryotes, the evolutionary related protein sec61-alpha plays a role in protein translocation through the endoplasmic reticulum; it is part of atrimeric complex that also consist of sec61-beta and gamma [ ].This entry represents two conserved sites for secY. The first corresponds to the second transmembrane region, which is the most conservedsection of these proteins. The second spans the C-terminal part of the fourth transmembrane region, a short intracellular loop, and the N-terminal part ofthe fifth transmembrane region.
Short Name	SecY_CS