Protein Domain : Reversion-inducing cysteine-rich protein with Kazal motifs IPR039016

Type  Family
Description  Reck is a GPI-anchored membrane protein that negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity [ ]. It also regulates two other MMPs, MMP-2 and MT1-MMP, known to be involved in cancer progression [, ]. Reck and the orphan receptor Gpr124 interact to activate Wnt7a/Wnt7b signaling in CNS vascular development [, ].
Short Name  RECK

0 Child Features

0 Gene Families

0 Genes

2 Ontology Annotations

0 Parent Features

0 Publications

USDA
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