Protein Domain : Colicin E1 (microcin) immunity protein IPR003061

Type	Family
Description	The structural and functional relationships among independently clonedsegments of the plasmid ColE1 region that regulates and codes for colicin E1 (cea), immunity (imm) and the mitomycin C-induced lethality function (lys)have been analysed [ ]. A model for the structure and expression of the colicin E1 operon has been proposed in which the cea and lys genes are expressed from a single inducible promoter that is controlled by the lexArepressor in response to the SOS system of Escherichia coli [ ]. The imm gene lies between the cea and lys genes and is expressed by transcription in the opposite direction from a promoter located within the lys gene [].This arrangement indicates that the transcriptional units for all three genes overlap. It is proposed that the formation of anti-sense RNA may be an important element in the coordinate regulation of gene expression in this system []. Hydropathy analysis of the imm gene products suggests that they have hydrophobic domains characteristic of membrane-associated proteins [].The microcin E1 immunity protein is able to protect a cell that harbours the plasmid ColE1 encoding colicin E1 against colicin E1; it is thusessential both for autonomous replication and colicin E1 immunity [ ].
Short Name	Microcin