Protein Domain : Salmonella invasion protein InvJ IPR003066

Type	Family
Description	The Salmonella typhimurium surface presentation of antigens N/invasion protein J gene (SpaN/InvJ) is one of 12 that form a cluster responsible for invasion properties. The gene product is required for entry by the bacterium into epithelial cells, and is thus considered to be a virulence factor [ ]. Other Spa genes in the cluster are related to invasion (Inv) genes in similar Salmonella and Shigella species [], and to flagella biosynthesis genes in Helicobacter pylori [].Functional analysis of the gene product from SpaN/InvJ has revealed the protein to have a molecular weight of 36.4kDa []. It is required by the organism to gain access to mammalian epithelial cells, and cellular mutants (InvJ-) fail successfully to infect these cells.It has been found, also, that the inv-spa loci of Salmonella species encode a type III protein secretion system, essential to the bacterium'shost cell invasion process [ ]. Suprisingly, type III-secreted proteinslack the customary signal sequence characteristic of most bacterial secretory peptides [].
Short Name	Invas_InvJ