Protein Domain : Pentaxin, conserved site IPR030476

Type	Conserved_site
Description	Pentaxins (or pentraxins) [ , ] are a family of proteins which show, underelectron microscopy, a discoid arrangement of five noncovalently bound subunits. Proteins known to belong to this family are:C-reactive protein (CRP), a protein which, in mammals, is expressed during acute phase response to tissue injury or inflammation. CRP displays severalfunctions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation throughits calcium-dependent binding to phosphorylcholine. CRPs have also been sequenced in an invertebrate, the Atlantic horseshoe crab, where they are anormal constituent of the hemolymph.Serum Amyloid P-component (SAP), a precursor of amyloid component P which is found in basement membrane and is associated with amyloid deposits.Hamster female protein (FP), a plasma protein whose concentration is altered by sex steroids and stimuli that elicit an acute phase response.A number of proteins, whose function is not yet clear, contain a C-terminal pentaxin-like domain. These proteins are:Human PTX3 (or TSG-14). PTX3 is a cytokine-induced protein.Guinea pig apexin [ ], a sperm acrosomal protein. Apexin seems to be theortholog of human neuronal pentraxin II (gene NPTX2) [ ].Rat neuronal pentaxin I [ ].The sequences of the different members of this family are quite conserved. This entry represents a six residue pattern which includes a cysteine known to be involved in a disulfide bridge in CRPs and SAP.
Short Name	Pentaxin_CS