Protein Domain : Serine/arginine-rich splicing factor 1, RNA recognition motif 2 IPR029538

Type  Domain
Description  Serine/arginine-rich (SR) proteins constitute a conserved family of RNA-binding proteins with roles in both constitutive and alternative splicing [ ]. Typically, SR proteins contain an N-terminal RNA-binding domain and a C-terminal RS domain that acts to promote protein-protein interactions [].This entry represents the second RNA recognition motif (RRM2) of serine/arginine-rich splicing factor 1 (SRSF1 or SF2/ASF). SF2/ASF regulates constitutive and alternative splicing [ ]. It has also been shown to regulate diverse aspects of gene regulation, including mRNA stability [], translation [], and transcription []. SF2/ASF is upregulated in several human tumours, including lung, colon, kidney, liver, pancreas and breast tumours [].
Short Name  SRSF1_RRM2
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