Protein Domain : Mitochondrial import inner membrane translocase subunit TIM22 IPR039175

Type  Family
Description  The membrane-embedded multi-protein complexes of mitochondria mediate the transport of nuclear-encoded proteins across and into the outer or inner mitochondrial membranes [ ]. Two translocases of the inner mitochondrial membrane (TIM22 and TIM23 complexes) mediate protein transport at the inner membrane.The TIM22 complex (a twin-pore carrier translocase) catalyses the insertion of multi-spanning proteins that have internal targeting signals into the inner membrane. The TIM22 complex mediates the membrane insertion of multi-spanning inner-membrane proteins that have internal targeting signals, and it uses the membrane potential as an external driving force [ ]. The Tim22 subunit of the mitochondrial import inner membrane translocase is included in this family. Tim22 forms a hydrophilic, high-conductance channel with distinct opening states and pore diameters, that is voltage-activated and specifically responds to an internal targeting signal [].
Short Name  TIM22

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