Protein Domain : Endonuclease III-like protein 1 IPR030841

Type  Family
Description  This entry includes human endonuclease III-like protein 1 (NTH1) and its homologues from animals, yeasts and plants. NTH1 is a bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyses the first step in base excision repair (BER), the primary pathway for the repair of oxidative DNA damage [ ]. In budding yeasts it is also known as Ntg1, which has an a paralogue, Ntg2 []. Yeast Ntg1 creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress [].
Short Name  NTH1

0 Child Features

0 Gene Families

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5 Ontology Annotations

0 Parent Features

0 Publications

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