Protein Domain : Synergist-CTERM protein sorting domain IPR030821

Type	Domain
Description	This entry represents a 27 residue domain containing features such as: 1) a short Gly/Ser-rich region that ends in an invariant Gly-Cys motif, 2) a highly hydrophobic probable transmembrane alpha helix with a nearly invariant Pro near the end, and 3) a cluster of basic residues (Arg, Lys), and then the end of the protein. This domain occurs only in species of Synergistetes. It closely resembles the MXYO-CTERM domain of the Myxococcales, a division of the Deltaproteobacteria ( ). However, MXYO-CTERM domain lacks the the conserved Pro, frequently has two Cys residues instead of one, and most importantly, has a spacer region separating the Gly-Cys motif from the transmembrane segment. As with MYXO-CTERM, the enzyme presumed to recognise and cleave the sorting signal is not known. The lack of a spacer region between motif and TM segment suggests the presumed protease is located largely within the membrane, like rhombosortase and archaeosortase, rather than merely tethered to it like sortase.
Short Name	Synergist_CTERM