Protein Domain : Rho GTPase-activating protein 11 IPR042869

Type  Family
Description  This entry includes ARHGAP11A and ARHGAP11B from humans. ARHGAP11B gene arose from partial duplication of ARHGAP11A (which encodes a Rho guanosine triphosphatase-activating protein) on the human lineage after separation from the chimpanzee lineage [ ]. A lack of 55 nucleotides in ARHGAP11B mRNA leads to loss of RhoGAP activity by GAP domain truncation and addition of a human-specific C-terminal amino acid sequence []. ARHGAP11B promotes basal progenitor amplification and is implicated in neocortex expansion [].
Short Name  ARHGAP11A/B

0 Child Features

0 Gene Families

0 Genes

0 Ontology Annotations

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