Protein Domain : Disease resistance protein, RPW8-like IPR039203

Type	Family
Description	Arabidopsis RPW8.1 and RPW8.2 genes confer broad-spectrum resistance to powdery mildew [ , ]. RPW8.2 is specifically targeted to the extrahaustorial membrane (EHM), where it activates haustorium-targeted resistance against powdery mildew []. This family includes RPW8.2 and homologues of RPW8 (HR), also known as RPW8-like proteins. HRs also contribute to basal resistance to powdery mildew, and HR1 to HR3 have been shown to localize to the EHM, suggesting that this could be a feature of the family [].Plants are attacked by a range of phytopathogenic organisms, including viruses, mycoplasma, bacteria, fungi, nematodes, protozoa and parasites. Resistance to a pathogen is manifested in several ways and is often correlated with a hypersensitive response (HR), localised induced cell death in the host plant at the site of infection [ , ]. The induction of the plant defence response that leads to HR is initiated by the plants recognition of specific signal molecules (elicitors) produced by the pathogen; R genes are thought to encode receptors for these elicitors. RPS2, N and L6 genes confer resistance to bacterial, viral and fungal pathogens.Sequence analysis has shown that they contain C-terminal leucine-rich repeats, which are characteristic of plant and animal proteins involved in protein-protein interactions [ ]. In addition, the sequences contain a conserved nucleotide-binding site towards their N-terminal.
Short Name	RPW8-like