Protein Domain : Ras-related protein Rab14 IPR030702

Type  Family
Description  Ras-related protein Rab14 is a small GTPase that mediates endocytic recycling and functions in phagosome maturation [ , ]. Rab14 and its exchange factor FAM116 regulates the specific endocytic transport of ADAM10 and thereby N-cadherin shedding and cell motility [, ]. Rab14 regulates claudin-2 trafficking, which is required for epithelial morphogenesis []. It regulates apical targeting in polarised epithelial cells []. Rab14 also regulates the interaction of phagosomes with early endocytic compartments and the maturation of macrophage phagosomes containing the fungal pathogen Candida albicans []. Drosophila Rab14 mediates phagocytosis in the immune response to Staphylococcus aureus [].
Short Name  Rab14

0 Child Features

0 Gene Families

0 Genes

9 Ontology Annotations

1 Parent Features

0 Publications

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