Protein Domain : Glutathione peroxidase conserved site IPR029760

Type	Conserved_site
Description	Glutathione peroxidase (GSHPx) ( ) is an enzyme that catalyses the reduction of hydroxyperoxides by glutathione [ ]. Its main function is to protect against the damaging effect of endogenously formed hydroxyperoxides.In higher vertebrates, several forms of GSHPx are known, including a ubiquitous cytosolic form (GSHPx-1), a gastrointestinal cytosolic form (GSHPx-GI), a plasma secreted form (GSHPx-P), and an epididymal secretory form (GSHPx-EP). In addition to these characterised forms, the sequence of a protein of unknown function [ ] has been shown to be evolutionary related to those of GSHPx's. Escherichia coli protein btuE, a periplasmic protein involved in the transport of vitamin B12, is also evolutionary related to GSHPx's; the significance of this relationship is not yet clear. Escherichia coli protein btuE, a periplasmic protein involved in the transport of vitamin B12, is also evolutionary related to GSHPx's; the significance of this relationship is not yet clear. This conserved site consists of a octapeptide located in the central section of these proteins.
Short Name	GPX_CS