Protein Domain : Chromobox protein homolog 2 IPR042796

Type  Family
Description  Chromobox protein homolog 2 (CBX2) is a polycomb protein, responsible for polycomb-repressive complex 1 (PRC1) targeting to chromatin via recognition of the repressive mark H3K27me3 [ ]. CBX2 is required during sex determination to stabilize the testis fate by blocking the upregulation of bivalent ovary pathway genes []. It is overexpressed in breast cancer and plays an essential role in tumour progression [, ].
Short Name  CBX2
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