Protein Domain : CDK5 regulatory subunit-associated protein 2 IPR042791

Type  Family
Description  CDK5 regulatory subunit-associated protein 2 (CDK5RAP2) is a centrosomal protein that regulates centrosomal maturation by recruitment of a gamma-tubulin ring complex (gamma-TuRC) onto centrosomes [ ]. It interacts directly with EB1, a prototypic member of microtubule plus-end tracking proteins. The CDK5RAP2-EB1 complex regulates microtubule dynamics and stability []. CDK5RAP2 also interacts with Cep169, a microtubule plus-end-tracking centrosomal protein; this interaction regulates stability of microtubules []. Mutations in the CDK5RAP2 gene cause microcephaly 3, primary, autosomal recessive (MCPH3) [, ].
Short Name  CDK5RAP2

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1 Ontology Annotations

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