Protein Domain : Virion membrane protein, poxvirus L1-related IPR003472

Type	Family
Description	The four families of large eukaryotic DNA viruses, Poxviridae, Asfarviridae, Iridoviridae, and Phycodnaviridae, referred to collectively as nucleocytoplasmic large DNA viruses or NCLDV, have all been shown to have a lipid membrane, in spite of the major differences in virion structure. The paralogous genes L1R and F9L encode membrane proteins that have a conserved domain architecture, with a single, C-terminal transmembrane helix, and an N-terminal, multiple-disulphide-bonded domain. The conservation of the myristoylated, disulphide-bonded protein L1R/F9L in most of the NCLDV correlates with the conservation of the thiol-disulphide oxidoreductase E10R which, in vaccinia virus, is required for the formation of disulphide bonds in L1R and F9L [ ].This entry also includes Inner membrane protein pE248R from African swine fever virus. This protein is essential for viral fusion with host endosomal membrane and core release. [ ].
Short Name	Virion_mem_poxvirus_L1