Protein Domain : Borrelia outer surface protein E/F IPR003483

Type  Family
Description  This is a family of outer surface proteins (Osp) from the Borrelia spp. spirochete [ ]. The family includes OspE, OspF, and OspEF-related proteins (Erp) []. These proteins are coded for on different circular plasmids in the Borrelia genome.Borrelia burgdorferi spirochetes, that cause Lyme borreliosis, survive for a long time in human serum due to their ability to succesfully evade the complement system, an important arm of innate immunity. The outer surface protein E (OspE) of B. burgdorferi is required for this since it recruits complement regulator factor H (FH) onto the bacterial surface to evade complement-mediated cell lysis [].
Short Name  OspEF

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