Protein Domain : Leucine rich adaptor protein 1/25 IPR039499

Type	Family
Description	This entry includes a group of leucine rich adaptor proteins, including LURAP1 (LRAP35A), LURAP1L and LRAP25. LURAP1 activates the canonical NF-kappa-B pathway, promotes proinflammatory cytokine production and promotes the antigen presenting and priming functions of dendritic cells [ ]. LRAP25, also known as C184M or MMTV receptor, is a Ski (a transcriptional co-repressor) binding protein that negatively regulates tumour growth factor-beta signaling by sequestering the Smad proteins in the cytoplasm [ ]. LRA25 also serves as an adaptor protein of MRCK (myotonic dystrophy kinase-related Cdc42-binding kinase) [].
Short Name	LURA1/LRA25