Protein Domain : Protein Spire homolog 1, FYVE-related domain IPR029905

Type	Domain
Description	This entry represents the FYVE-related domain of Spire homolog 1 (Spir-1) and similar proteins from chordates. Spir-1 acts as an actin nucleation factor that remain associated with the slow-growing pointed end of the new filament [ , ]. It is involved in intracellular vesicle transport along actin fibres, providing a novel link between actin cytoskeleton dynamics and intracellular transport []. The structure of Spire has been revealed [, ]. It contains an N-terminal KIND (kinase noncatalytic C-lobe) domain and four actin-binding WH2 (WASP homology 2) domains, a Rab GTPase-interaction Spir-box, and a C-terminal FYVE zinc-binding domain (this entry) []. The mammalian genome encodes two Spir proteins, Spir-1 and Spir-2. In adult tissues, the spir-2 gene shows a rather broad expression pattern, whereas spir-1 is mainly expressed in neuronal cells of the nervous system. Spir-1 may have a role in neural function [ ].
Short Name	Spir-1_FYVE-rel_dom