Protein Domain : Homeobox protein MIXL1 IPR042917

Type  Family
Description  Mixl1 is a homeobox transcription factor essential for the patterning of axial mesendodermal structures during early embryogenesis [ , ]. It interacts with the T-box protein Brachyury and related members of the T-box family of transcription factors; this interaction negatively regulates Mixl1 transcriptional activity []. In mice, enforced expression of Mixl1 results in transplantable AML (acute myeloid leukemia), suggesting a leukemogenic potential for Mixl [].
Short Name  MIXL1

0 Child Features

0 Gene Families

0 Genes

3 Ontology Annotations

0 Parent Features

0 Publications

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