Protein Domain : Vinculin IPR017997

Type	Family
Description	Vinculin is an actin filament (F-actin) binding protein involved in cell-matrix adhesion and cell-cell adhesion [ ]. In addition to actin, vinculin interacts with other structural proteins such as talin and alpha-actinins [].Vinculin is a large protein of 116kDa (about a 1000 residues). Structurally the protein consists of an acidic N-terminal domain of about 90kDa separated from a basic C-terminal domain of about 25kDa by a proline-rich region of about 50 residues. The central part of the N-terminal domain consists of a variable number (3 in vertebrates, 2 in Caenorhabditis elegans) of repeats of a 110 amino acids domain. Interestingly, vinculin exists in two conformations in the cell: an open, active form and a closed, auto-inhibited state in which the head domain forms extensive interactions with the tail [ ].
Short Name	Vinculin