Protein Domain : Insulinoma-associated protein 1/2 IPR042972

Type	Family
Description	Insulinoma-associated protein 1 (INSM1) is a zinc-finger transcription factor exclusively expressed in the foetal pancreas and nervous system, and in tumours of neuroendocrine origin. It can recruits cyclin D1 and HDACs, which confer transcriptional repressor activity [ ]. It is involved in endocrine and neuronal cell differentiation []. In pancreas, it is activated by the islet-specific endocrine factor neurogenin 3, and subsequently regulates downstream target genes NeuroD1 and insulin during beta-cell maturation [].Transcription factor egl-46 is the C. elegans orthologue from human INSM2, which is involved in neuron differentiation [ ].
Short Name	INSM1/2