Protein Domain : Ras GTPase-activating protein IPR039360

Type	Family
Description	Ras proteins are membrane-associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP []. This intrinsic GTPase activity of Ras is regulated by a family of proteins collectively known as 'GAP' or GTPase-activating proteins [, ]. RasGAP proteins are usually quite large (from 765 residues for sar1 to 3079residues for IRA2) but share only a limited (about 250 residues) region of sequence similarity, referred to as the 'catalytic domain' or RasGAP domain.The most conserved region within this domain contains a 15 residue motif which seems to be characteristic of this family of proteins []. Note: There are distinctly different GAPs for the Rap and Rho/Rac subfamilies of Ras-like proteins that do not share sequence similarity with Ras GAPs [ ].
Short Name	Ras_GTPase