Protein Domain : Nuclear translocator IPR001067

Type  Family
Description  The Ah (dioxin) receptor nuclear translocator protein (Arnt) belongs to the basic helix-loop-helix (bHLH) family of transcription factors and is required for Ah receptor function. The Ah receptor binds, and mediates the carcinogeniceffects of a variety of environmental pollutants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin and polycyclic aromatic hydrocarbons. Arnt is a structural component of the XRE-binding form of the Ah receptor. These proteins are class VII members of the basic helix-loop-helix (bHLH) family. The bHLH domain may be responsible for interacting with both the XRE and the ligand-bindingsubunit [ , ].The activated Ah receptor and Arnt protein bind DNA as a heterodimer. Both proteins contain PAS homology regions, which in Drosophila PER and SIMproteins function as dimerisation domains [ ].
Short Name  Nuc_translocat

0 Child Features

0 Gene Families

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5 Ontology Annotations

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