Protein Domain : Salmonella/Shigella invasion protein E IPR003520

Type	Family
Description	Secretion of virulence factors in Gram-negative bacteria involves transportation of the protein across two membranes to reach the cell exterior. There have been four secretion systems described in sequence similarities in plant pathogens like Ralstonia and Erwinia [].The type III secretion system is of great interest, as it is used to transport virulence factors from the pathogen directly into the host cell [ ] and is only triggered when the bacterium comes into close contact withthe host. The protein subunits of the system are very similar to those of bacterial flagellar biosynthesis. However, while the latter forms aring structure to allow secretion of flagellin and is an integral part of the flagellum itself [], type III subunits in the outer membranetranslocate secreted proteins through a channel-like structure. The Salmonella/Shigella invasion protein E gene (InvE) is one such type III secretion protein subunit, and is localised to the outer membrane of the SPI I pathogenicity island, and is involved in the surface presentation.
Short Name	Invas_InvE