Protein Domain : Protein KASH5, EF-hand-like domain IPR039508

Type	Domain
Description	This entry represents the EF-hand-like domain found in protein KASH5. KASH5 is a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton [ ]. It interacts (via the last 22 AA) with SUN1; this interaction mediates telomere localisation []. Proteins containing this domain also include lrmp from Zebra fish. It is a maternally expressed membrane and cytoskeletal linker protein, which is essential for attachment of the centrosome to the male pronucleus [ ].
Short Name	KASH5_EF-hand-like_dom