Protein Domain : Dynein regulatory complex protein 1/2, N-terminal IPR039505

Type	Domain
Description	This entry represents the N-terminal domain of dynein regulatory complex protein 1/2 (DRC1/2). DRC1 is a key component of the nexin-dynein regulatory complex (N-DRC), essential for N-DRC integrity. It is required for the assembly and regulation of specific classes of inner dynein arm motors. It may also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending [ ]. Mutations of DRC1 gene cause Ciliary dyskinesia, primary, 21 (CILD21), which is a disorder characterised by abnormalities of motile cilia [ ]. DRC2, also known as CCDC65, is an essential component of the nexin-dynein regulatory complex [ ].
Short Name	DRC1/2_N