Protein Domain : Cytochrome c-type biogenesis protein NrfE IPR003570

Type	Family
Description	Within mitochondria and bacteria, a family of related proteins is involved in the assembly of periplasmic c-type cytochromes: these include CycK [ ], CcmF [, ], NrfE [] and CcbS []. These proteins may play a role in guidance of apocytochromes and haem groups for their covalent linkage by the cytochrome-c-haem lyase. Members of the family are probably integral membrane proteins, with up to 16 predicted transmembrane (TM) helices.A seven-gene operon, designated nrf, has been shown to be essential for formate-dependent nitrite reduction to ammonia by enteric bacteria [ ]. Expression of lac fused to nrfA, nrfE or nrfG is regulated by oxygen repression, FNR-dependent anaerobic induction, nitrite induction and nitrate repression during anaerobic growth. NrfE is a hydrophobic, integral membrane protein that shares a high degree of similarity with the CdI1 protein of Rhodobacter capsulatus implicated in the assembly of periplasmic c-type cytochromes []. Hydropathy analysis reveals up to 16 putative TM domains.
Short Name	Cyt_c_biogenesis_NrfE