LIS - Legume Information System
Information about legume traits for crop improvement
CicerMine
v5.1.0.3
Cicer data from the Legume Information System
v5.1.0.3
Cicer data from the Legume Information System
| Type | Domain |
| Description | Lem4 (also called ANKLE2) and C. elegans orthologue LEM-4L are required for BAF dephosphorylation. Lem4 coordinates BAF dephosphorylation by inhibiting kinase VRK-1 and by supporting PP2A dephosphorylation of BAF during mitotic exit [ ].Barrier-to-autointegration factor (BAF) is an essential protein that binds to dsDNA, chromatin, nuclear lamina proteins, histones and various transcription factors [ ]. Members of the vaccinia-related kinase (VRK) family of mitotic kinases phosphorylate BAF in mitosis and meiosis; this modification strongly reduces the affinity of BAF for chromatin and slightly weakens its affinity for LEM proteins. BAF dephosphorylation has been linked to mitotic exit and postmitotic NE formation [].ANKLE2 contains an N-terminal LEM domain and an ankyrin repeat region. The LEM domain is known to interact with BAF []. The ankyrin repeats are unique motifs mediating protein-protein interactions.This entry represents the LEM domain. |
| Short Name | LEM_ANKL2 |
