Protein Domain : RNA-directed RNA polymerase, C-terminal domain IPR001205

Type	Domain
Description	This entry represents the C-terminal domain of the RNA-directed RNA polymerase (RdRp) found in many positive strand RNA eukaryotic viruses. It is part of the genome polyprotein that contains other polypeptides such as coat proteins VP1 to VP4, core proteins P2A to P2C and P3A, genome-linked protein VPG and picornain 3C ( ). Structural studies indicate that these proteins form the "right hand"structure found in all oligonucleotide polymerases, containing thumb, finger and palm domains, and also the additional bridging finger and thumb domains unique to RNA-directed RNA polymerases [ , , , ].Remdesivir, a recent treatment approved for Covid-19 disease, directly interacts with this region of the RdRp (NSP12) from SARS-CoV-2 and explains its mechanism of action via delayed-chain termination [ ].
Short Name	RNA-dir_pol_C