Protein Domain : Protein SPO16 homolog IPR027857

Type  Family
Description  This entry represents the Protein SPO16 homologue (SPO16, also known as Synaptonemal complex reinforcing element SCRE), including the mammalian orthologue of budding yeast Spo16. It plays a key role in reinforcing the integrity of the central element of the synaptonemal complex (SC), resulting in the SC stabilization which ensures the progression of meiotic prophase I in male and female germ cells [ . It promotes homologous recombination and crossing-over in meiotic prophase I via its association with SHOC1 [ ]. It is also required for the localization of TEX11 and MSH4 to recombination intermediates [].
Short Name  SCRE

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1 Ontology Annotations

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