Protein Domain : Wings apart-like protein IPR039874

Type  Family
Description  Wings apart-like protein (WAPL) regulates heterochromatin structure [ ]. It is required to hold sister chromatids of meiotic heterochromatin together and is implicated in both heterochromatin pairing during female meiosis and the modulation of position-effect variegation (PEV) []. hWAPL (), the human homologue, is found to play a role in the development of cervical carcinogenesis, and is thought to have similar functions to Drosophila wapl protein [ ]. Malfunction of the hWAPL pathway is thought to activate an apoptotic pathway that consequently leads to cell death [].
Short Name  WAPL

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