Protein Domain : Recombination activating protein 2, PHD domain IPR025162

Type	Domain
Description	RAG-2 is an essential component of the lymphoid-specific recombination activating gene RAG1/2 V(D)J recombinase mediating antigen-receptor gene assembly. It contains an acidic hinge region implicated in histone-binding, a non-canonical plant homeodomain (PHD) finger followed by a C-terminal extension of 40 amino acids that is essential for phosphoinositide (PtdIns)-binding. [ , , ].This domain, a non-canonical plant homeodomain (PHD) finger, is found at the C terminus of the Recombination activating gene 2 (RAG2) protein. The PHD finger is a chromatin-binding module that has been shown bound to histone H3 trimethylated at lysine 4 (H3K4me3) and influences V(D)J recombination [ ].
Short Name	RAG2_PHD