Protein Domain : E3 ubiquitin-protein ligase SH3RF2, second SH3 domain IPR035794

Type  Domain
Description  SH3RF2 is also called POSHER (POSH-eliminating RING protein) or HEPP1 (heart protein phosphatase 1-binding protein). It acts as an anti-apoptotic regulator of the JNK pathway by binding to and promoting the degradation of SH3RF1 (or POSH), a scaffold protein that is required for pro-apoptotic JNK activation [ ]. It may also play a role in cardiac functions together with protein phosphatase 1 []. SH3RF2 contains an N-terminal RING finger domain and three SH3 domains. This entry represents the second SH3 domain of SH3RF2.
Short Name  SH3RF2_SH3_2

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