Protein Domain : Fosfomycin resistance protein FosX IPR037434

Type  Family
Description  FosX is a Mn(II)-dependent fosfomycin-specific epoxide hydrolase [ ]. Fosfomycin inhibits the enzyme UDP-Nacetylglucosamine-3-enolpyruvyltransferase (MurA), which catalyzes the first committed step in bacterial cell wall biosynthesis. FosX catalyzes the addition of a water molecule to the C1 position of the antibiotic with inversion of the configuration at C1 in the presence of Mn(II). The hydrated fosfomycin loses the inhibition activity []. FosX is evolutionarily related to glyoxalase I and type I extradiol dioxygenases.
Short Name  FosX

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