Protein Domain : Peroxisome biogenesis protein 22 IPR037485

Type	Family
Description	Peroxisomal proteins, called peroxins, participate in the process of peroxisome assembly. Specific amino acid sequences (PTS or peroxisomal targeting signal) at the C terminus (PTS1) or N terminus (PTS2) are present in peroxisomal matrix proteins, which signals them to be imported. The protein receptors Pex5 and Pex7 accompany their cargoes (containing a PTS1 or a PTS2 amino acid sequence, respectively) into the peroxisome. Ubiquitination appears to be crucial for the export of Pex5 from the peroxisome to the cytosol. The monoubiquitination of the PTS1-receptor Pex5p is catalyzed by the E2 enzyme Pex4.Pex22 anchors Pex4 to the peroxisome membrane [ , ]. Moreover, Pex4 requires the interaction with Pex22 to display full activity []. The N-terminal portion of Pex22 has a membrane anchoring function, whereas the C-terminal domain harbours its biological activity. The soluble C-terminal domain of Pex22 is essential for peroxisomal biogenesis and efficient monoubiquitination of the import receptor Pex5 [].
Short Name	PEX22