Protein Domain : CLAVATA3/ESR (CLE)-related protein 41/44 IPR037495

Type	Family
Description	This entry includes CLAVATA3/ESR (CLE)-related protein 41/44 (CLE41/44) from Arabidopsis and TDIF from Zinnia violacea. TDIF functions as a phloem-derived, non-cell-autonomous signal that controls stem cell fate in the procambium [ ].Tracheary element differentiation inhibition factor (TDIF and CLE41/CLE44 peptides act as inhibitors of tracheary element differentiation. TDIF/CLE41/CLE44 promote the proliferation of vascular cells and prevent them from differentiating into xylem by regulating WOX4 expression through the TDR/PXY receptor [ , , ]. CLE42 binds PXL2 (PXY-like 2) []. TDIF-related peptides also have activity to enhance axillary bud formation [].The CLE proteins share a C-terminal CLE domain with CLV3, a small secreted polypeptide that is active as a ligand and has a function in shoot apical meristem maintenance [ ]. In general, the CLE-related proteins are C-terminally processed to generate an active CLE peptide []. These small secreted peptide hormones then function in a variety of developmental and physiological processes [, ]. CLV3 and other A-type CLE peptides are involved in the suppression of stem cell development in root and shoot development, in contrast to the B-type CLE peptides, CLE41 and CLE44, in the case of Arabidopsis, which are not [].
Short Name	CLE41/44