Protein Domain : Nuclear anchorage protein 1-like IPR039906

Type	Family
Description	This entry represents the nuclear anchorage protein 1 (ANC-1) and related proteins, from arthropods and nematodes (roundworms). ANC-1 contains a conserved Klarsicht/ANC-1/Syne homology (KASH) domain at its C terminus that can associate with Sad1p/UNC-84 (SUN)-domain proteins of the inner nuclear membrane within the periplasmic space of the nuclear envelope (NE) [ ]. In C. elegans, ANC-1 connects nuclei to the cytoskeleton by interacting with UNC-84 at the nuclear envelope and with actin in the cytoplasm [, ]. This entry also includes Klarsicht protein from Drosophila melanogaster, a protein that links microtubule motors and various cellular structures. It is important to control the migration and positioning of nuclei in photoreceptors and muscles [, ].
Short Name	Anc-1-like