Protein Domain : Vacuolar protein sorting 38 IPR040939

Type	Family
Description	This entry includes Vps38 from budding yeasts. Vps38 is involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II [ ].The class III phosphatidylinositol-3-kinase (PI3K) known as Vps34 regulates intracellular membrane trafficking in endocytic sorting, cytokinesis and autophagy. Vps34 forms complexes with other proteins: Vps15, Vps30 (encoded by VPS30/ATG6 in yeast, equivalent to mammalian Beclin 1, encoded by BECN1) and either Vps38 (UVRAG) or Atg14 (ATG14L). Although the N-terminal domains of Vps30, Vps38 and Atg14 differ, the overall similarity of their domain organizations suggests that these proteins may have evolved from a common ancestor [].
Short Name	Vps38