Protein Domain : Upstream-binding protein 1, SAM domain IPR037600

Type	Domain
Description	Ubp1 (also known as LBP-1) is involved in transcriptional regulation from early development to terminal differentiation. It regulates alpha-globin in erythroid cells and P450scc (the cholesterol side-chain cleavage enzyme, cytochrome) in human placenta [ ]. Human Ubp1 is known to be induced by HIV type I infection in lymphocytes; it represses HIV transcription by preventing the binding of TFIID to the virus promoter []. Ubp1 might also be part of a network controlling blood pressure []. Ubp1 contains an N-terminal DNA-binding CP2 domain and a central SAM domain. Ubp1 protein isoforms are able to form dimers via their SAM domain [ ].
Short Name	Ubp1_SAM