Protein Domain : Tumour protein p63, SAM domain IPR037611

Type	Domain
Description	The transcription factor p63 shares protein sequence similarity with the tumour suppressor p53 [ ]. It plays an important part in maintaining the progenitor basal cell populations in stratified epithelium []. It is also involved in heart development and human reproduction []. Two p63 isoforms, the "trans-activating"isoforms and "truncated"isoforms, have been identified in humans. These isoforms may have different roles in skin, heart and germ line [ ].This entry represents the SAM domain of tumour protein p63. SAM domain is a putative protein-protein interaction domain. Mutations in the SAM domain of p63 are found in AEC (ankyloblepharonectodermal dysplasia-clefting) syndrome patients [ ].
Short Name	Tumor-p63_SAM