Protein Domain : Twist-related protein 1, basic helix-loop-helix domain IPR047093

Type  Domain
Description  This entry represents the basic helix-loop-helix (bHLH) domain found in Twist1 and related proteins mainly from vertebrates.Twist-related protein 1 (Twist1) is a bHLH transcriptional regulator that inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. It also represses expression of proinflammatory cytokines such as TNFA and IL1B [ , ] and plays an essential role in tooth morphogenesis []. In addition, Twist1 is involved in cancer development and progression [, , ]. Mutations in this protein are associated with other genetic human diseases with symptoms related to malformations [, ].
Short Name  TWIST1_bHLH
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