Protein Domain : Alpha-1-acid glycoprotein IPR001500

Type	Family
Description	The name 'lipocalin' has been proposed [ ] forthe larger protein family, but cytosolic fatty-acid binding proteins are also included. The sequences of most members of the family, the core or kernal lipocalins, are characterised by three short conserved stretches of residues, while others, the outlier lipocalin group, share only one or two of these[ , ]. Proteins known to belong to this family include alpha-1-microglobulin (protein HC);alpha-1-acid glycoprotein (orosomucoid) [ ]; aphrodisin; apolipoprotein D; beta-lactoglobulin; complementcomponent C8 gamma chain [ ]; crustacyanin []; epididymal-retinoic acid binding protein(E-RABP) [ ]; insectacyanin; odorant-binding protein (OBP); human pregnancy-associated endometrial alpha-2globulin; probasin (PB), a rat prostatic protein; prostaglandin D synthase [ ]; purpurin; VonEbner's gland protein (VEGP) [ ]; and Lacerta vivipara (Common lizard) epididymal secretory protein IV (LESP IV) [ ].Alpha-1-acid glycoprotein (orosomucin) (A1AG) is a major serum glycoprotein of unknown physiological function []. It has been implicated in cellularinflammation by increasing tissue factor expression and tumour necrosis factor alpha secretion of monocytes. The protein is associated with fiveasparaginyl-linked complex oligosaccaride chains, the proportions and identities of which are altered in several physiological and pathologicalconditions [ ]. A1AG is also clinically important as a non-specific drugbinder in serum [ ]. It has recently been shown to bind tothalidomide, which may be involved in its inhibition of tumor necrosis factor alpha production [].
Short Name	A1A_glycop