Protein Domain : Salmonella invasion protein A, chaperone-binding IPR023225

Type  Homologous_superfamily
Description  Salmonella invasion protein A (SipA) is a virulence factor that is translocated into host cells by a type III secretion system. In the host cell it binds to actin, stimulates actin polymerisation and counteracts F-actin destabilising proteins. This contributes towards cytoskeletal rearrangements that allow the entry of the pathogen into the host cell [ ]. The chaperone-binding domain of SipA consists of a globular domain, represented by this entry, and an adjacent nonglobular polypeptide [ ]. Both of these elements are necessary for chaperone binding to occur. The globular domain is composed of eigth alpha helices arranged so that six amphipathic helices surround a predominantly hydrophobic helix in the middle.
Short Name  SipA_chaperone-bd
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