Protein Domain : Retinoblastoma-binding protein 5/Swd1 IPR037850

Type  Family
Description  This entry includes RBBP5 from animals, RBL from plants and Swd1 from yeasts. Swd1 is a component of the SET1C/COMPASS complex, a complex that methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres [ , ].Retinoblastoma-binding protein 5 (RBBP5) is important for development in embryonic stem cells, regulating gene induction and H3 'Lys-4' methylation at key developmental loci [ ]. It is a component of the SET1 histone methyltransferase complex [], and methyltransferase-containing (COMPASS) complexes MLL1, MLL2/3 and MLL4 [, ].Arabidopsis RBL is also a component of a COMPASS-like complex that mediates histone H3 lysine-4 trimethylation to control floral transition and plant development [ ].
Short Name  RBBP5/Swd1
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