Protein Domain : Circadian locomoter output cycles protein kaput-like IPR047230

Type	Family
Description	This entry represents a group of animal proteins related to core components of the circadian clock, including the human proteins circadian locomoter output cycles protein kaput (CLOCK), neuronal PAS domain-containing protein 2 (NPAS2) and the circadian clock protein PASD1.CLOCK and NPAS2 are core clock components. CLOCK is a transcriptional activator that also has an intrinsic acetyltransferase activity, which enables circadian chromatin remodelling by acetylating histones and nonhistone proteins, including its own partner BMAL1 [ , , ]. NPAS2 mediates the diurnal variation in the expression of GABARA1 receptor in the brain and contributes to the regulation of anxiety-like behaviors and GABAergic neurotransmission in the ventral striatum [, ].PASD1 functions as a nuclear repressor of the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock components, acting as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body [ ].
Short Name	CLOCK-like