Protein Domain : Polycomb protein SCMH1, second MBT repeat IPR047280

Type  Repeat
Description  This entry represents the second MBT repeat of SCMH1 and similar proteins specific to vertebrates. MTB repeats are protein modules that recognise methylated lysine residues on histones. This repeat contains a semi-aromatic cage to accommodate methylated lysine residues and show specificity towards the lower methylation states of lysines.Sex comb on midleg homologue 1 (SCMH1) is the mammal homologue of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats [ , , , , , ].
Short Name  MBT_SCMH1_rpt2
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