Protein Domain : Polycomb protein SCMH1, first MBT repeat IPR047279

Type  Repeat
Description  This entry represents the first MBT repeat of SCMH1 and similar proteins specific to vertebrates. MTB repeats are protein modules that recognise methylated lysine residues on histones. Unlike other MTB repeats, this repeat does not contain a semi-aromatic cage and may not bind methylated lysine residues.Sex comb on midleg homologue 1 (SCMH1) is the mammal homologue of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats [ , , , , , ].
Short Name  MBT_SCMH1_rpt1

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